Y Combinator’s Fall 2025 (F25) batch is officially in motion. An intense October–December sprint that compresses years of startup learning into just a few weeks.
And all eyes are now on Demo Day, happening on 3rd December, where these companies will make their debut to investors, operators, and the rest of Silicon Valley.
About Y Combinator (YC)
Y Combinator is the world’s most prestigious startup accelerator. It is the launchpad that shaped Airbnb, Stripe, Instacart, Dropbox, and hundreds more.
Since 2005, the accelerator has backed over 5,000 companies that have a combined valuation of over $800 billion.
Every selected startup receives $500K for 7% equity, alongside something far more valuable:
- Direct mentorship from world-class partners
- A no-nonsense path to product-market fit
- A community that founders lean on long after the batch ends
And like the rest of tech right now, F25 is overwhelmingly AI-native. This batch has close to 150+ startups, with the majority building AI-first products across B2B automation, healthcare, biotech, robotics, and enterprise infrastructure.
But within this broad wave, there’s a quieter and more important story unfolding.
The healthtech pulse of YC F25 Batch
The Fall 2025 batch is not as health-heavy as S25. However, the selected healthtech startups are tackling big, foundational problems: drug discovery, clinical workflows, payer operations, pharmacy automation, women’s health, and the microbiome.
These aren’t incremental tools. They’re infrastructure plays that aim to reshape how medicine is built, delivered, and reimbursed.
Here’s a closer look at the healthtech startups building in the YC F25 cohort right now:
#1 LunaBill
Founders: Suhail Parry, David Day, Yash Raj
Year: 2025 | Location: San Francisco, CA
LunaBill builds AI-powered voice callers that automate insurance claim follow-ups for healthcare billing teams. Their AI agents handle claim-status checks, appeals, and reprocessing calls, scaling like a full call center without the headcount.
#2 Rovi Health
Founders: Santosh Vallabhaneni, Tarun Vallabhaneni
Year: 2025 | Location: San Francisco, CA
Rovi Health is a text-first care platform helping employers reduce healthcare costs. Patients receive care via text or video, while AI agents guide them to high-value, in-network providers and assist with scheduling.
#3 Exonic
Founders: Ben Brimacombe
Year: 2025 | Location: San Francisco, CA
Exonic is building an open drug-discovery network powered by biological AI models and collaborative infrastructure, enabling faster development of new therapeutics.
#4 Anto Biosciences
Founders: Arvid Ernst Gollwitzer, David de Gruijl
Year: 2025 | Location: San Francisco, CA
Anto is developing multimodal foundation models for the gut microbiome. Their platform predicts how different microbial communities respond to drugs, aiming to optimize toxicity and efficacy.
#5 Nucleo
Founders: Angelica Iacovelli, Luca Pegolotti
Year: 2025 | Location: San Francisco, CA
Nucleo is building automated cancer diagnostics that turn raw CT scans into actionable insights within minutes. Their AI platform calculates key oncological metrics with 98% accuracy. By cutting diagnosis-to-treatment time from months to days, Nucleo aims to help clinicians make faster, more confident decisions and improve patient outcomes.
#6 Play Health
Founders: Andrea Mazzocchi, Ian Miller
Year: 2025 | Location: Boulder, Colorado
Play Health provides a personalized perimenopause care platform that combines symptom tracking, at-home hormone testing, and AI-driven insights to help women understand and manage hormonal changes.
#7 Kaigo Health
Founders: Peter Chien, Lukas Klaiber, Kazuki Shin
Year: 2024 | Location: San Francisco, CA
Kaigo Health offers an AI-powered outpatient care workforce for Medicare-focused providers, performing scalable post-discharge follow-ups, check-ins, and monitoring using calls enhanced by voice biomarkers.
#8 Norra
Founders: Ben Rubin, Yining Zhang
Year: 2025 | Location: San Francisco, CA
Norra is an AI-powered operations platform for nursing facilities, giving administrators real-time visibility into all their medical equipment. By creating a digital twin of the facility and tracking devices with custom hardware, Norra helps teams cut equipment waste, prevent downtime, and save over $100K per year through smarter purchasing and maintenance automation.
#9 Remedy
Founders: Nikhil Devaraj, Sai Mandhan, Vishnu Sreenivasan
Year: 2025 | Location: San Francisco, CA
Remedy builds AI agents for pharmacies, automating prescription refills, patient calls, and insurance follow-ups. By handling the repetitive administrative load, Remedy frees up pharmacists to focus on patient care and helps pharmacies run more efficiently.
#10 Nori
Founders: Harish Agarwal, Dave Zohrob
Year: 2025 | Location: New York
Nori is a personal health coach app that unifies all the data from Apple Health, Oura, Whoop, and other wearables. It uses AI to deliver personalized, evidence-based recommendations for recovery, energy, and metabolic health goals.
The big picture
The F25 healthtech cohort is smaller than S25, but the signal is strong:
AI is becoming the operational backbone of healthcare, from drug design to billing, from home health to clinical trials.
With Demo Day landing on 3rd December, these companies are about to show the world how AI-native healthcare companies scale, differentiate, and win.
